منابع مشابه
Spurious Hyperleukocytosis
Hyperleukocytosis is an oncological emergency but is extremely rare in non-malignant conditions. Nucleated RBCs give rise to spuriously high total leucocyte count and cause clinical dilemma. Thalassemia major patients are known to have leucocytosis even after correction for nucleated RBCs. We report a case of undiagnosed Thalassemia major in a 4 month old infant with total leucocyte count highe...
متن کاملContext dependence, ancestral misidentification, and spurious signatures of natural selection.
Population genetic analyses often use polymorphism data from one species, and orthologous genomic sequences from closely related outgroup species. These outgroup sequences are frequently used to identify ancestral alleles at segregating sites and to compare the patterns of polymorphism and divergence. Inherent in such studies is the assumption of parsimony, which posits that the ancestral state...
متن کاملCollider Scope: How selection bias can induce spurious associations
1. MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom. 2. UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, University of Bristol, Bristol, United Kingdom. 3. School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom. 4. University of Queensland Diamantina Institute, Translational Research Institute, ...
متن کاملThe effects of selection against spurious transcription factor binding sites.
Most genomes contain nucleotide sequences with no known function; such sequences are assumed to be free of constraints, evolving only according to the vagaries of mutation. Here we show that selection acts to remove spurious transcription factor binding site motifs throughout 52 fully sequenced genomes of Eubacteria and Archaea. Examining the sequences necessary for polymerase binding, we find ...
متن کاملspurious hyperleukocytosis
hyperleukocytosis is an oncological emergency but is extremely rare in non-malignant conditions. nucleated rbcs give rise to spuriously high total leucocyte count and cause clinical dilemma. thalassemia major patients are known to have leucocytosis even after correction for nucleated rbcs. we report a case of undiagnosed thalassemia major in a 4 month old infant with total leucocyte count highe...
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ژورنال
عنوان ژورنال: Journal of the Institute of Actuaries
سال: 1906
ISSN: 0020-2681,2058-1009
DOI: 10.1017/s0020268100008830